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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Dr. Muhammed Majeed, Dr. Raju Rhee, Smitha Thazhathidath, Mahesh Paschapur, Nataraj Eramuddappa, Kiran Kumar Vuppala*


Objective: To evaluate the safety and efficacy of a formulation, Dewderm AD cream, in patients with mild-to-moderate atopic dermatitis (AD). Methods: Thirty six subjects with mild-to-moderate AD aged between 5–55 years were enrolled in the study. All 36 patients were instructed to apply Dewderm AD cream twice daily on the affected area for 60 days irrespective of their visits to the clinic. Subjects underwent evaluation of efficacy parameters, such as effect of skin surface hydration and assessment of disease severity, quality of life at the end of the treatment, and photographs were taken before and after the treatment (i.e. on day 60) to assess clinical improvement of the severity of AD. Results: Treatment with Dewderm AD cream showed statistically significant improvement in all the efficacy parameters at different time points from baseline to end of the study. A statistically significant (p < 0.05) increase in mean skin surface hydration with 54.86% improvement at visit 5 was observed when compared to baseline. SCORAD score showed 80.22% reduction in the severity of skin lesions by the end of the treatment period suggesting progressive improvement in the disease severity. Similarly, the investigator‟s global assessment (IGA) scale also showed a statistically significant reduction of 67.01% from baseline 2.69 ± 0.47 to 0.88 ± 0.40 at the end of the study (p < 0.05). The DLQI score also demonstrated a statistically significant decrease (p < 0.05) from baseline to end of the study. Additionally, photograph comparing before and after treatment showed gradual clinical improvement in severity of AD of the affected area at the end of the study in subjects who had skin lesions at baseline. No adverse events were reported during the study. Conclusion: Dewderm AD cream was very effective in treating mild-to-moderate AD by significantly reducing the disease severity without any side effects. Hence, the formulation is an effective and safe treatment option in patients with mild-to-moderate AD.

Keywords: Atopic dermatitis, Investigator?s Global Assessment, Quality of Life.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia