EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

AN INVESTIGATION ON THE HEPATOTOXIC EFFECTS OF GASOLINE ON MALE WISTER RATS

*Seriki A. Samuel, Adebayo O. Francis, Ike C. Emmanuel, Nnanna J. Uche

ABSTRACT

The present study investigates the hepatotoxic effects of inhaled gasoline and gasoline contaminated diets on male wistar albino rats after four weeks of chronic exposure. Twelve (12) wistar albino rats were divided into three groups of four rats per group. Group One was established as the control group and was given normal rat feed and water, Group Two was subjected to gasoline inhalation, and Group Three was treated with gasoline contaminated feed. The LD50 value of gasoline was obtained as 128 mL kg-1body weight of rats. The animals exhibited changes in behavioural pattern such as respiratory distress and sedation. The animals were sacrificed by cervical dislocation 24 hours after the final day of administration. Serum alanine amino transferase (ALT), aspartate aminotransferase (AST), and alkaline phosphate (ALP) levels, four weeks after feeding the rats with gasoline contaminated diets increased significantly (p≤0.05). Also, these parameters (ALT, AST, and ALP) increased significantly, four weeks after subjecting the rats to gasoline inhalation (p≤0.05). Feeding the rats with gasoline contaminated feed for four weeks also resulted in remarkable decrease in final body weights and percentage weight increase of test animals compared to control group. This significant decrease was also seen in the group subjected to gasoline inhalation for four weeks. Histological examination of the liver indicated that gasoline contaminated diets induced significant degenerative changes in the structural integrity of the hepatic cells. These degenerative changes were also observed in the rats subjected to gasoline inhalation. The results obtained in this study suggest that long term inhalation and ingestion of gasoline induced stress which impaired liver structural integrity and functions.

Keywords: Gasoline, Hepatotoxicity, Liver, Structural Integrity, Liver Functions, cytolethality, Aspartateaminotransferase (AST), Alanineaminotransferase (ALT) and Alkaline phosphatase (ALP.

[Full Text Article] [Download Certificate]