RENAL FUNCTION IN SUDANESE PATIENTS WITH ESSENTIAL HYPERTENSION

Hind M Beheiry*, Ahmed M.S. Eltohami, Ibrahim A Ali, Mazin S A Mohamed, Ibtisam A Ali , Nasreldin A. Mahmoud

ABSTRACT

Background: The kidney is an important target of hypertension. Understanding of renal function is critical for prevention of hypertension and renal disease. Objectives: The main objective of this study was to detect the effect of primary hypertension on renal function in Sudanese male patients. Material and Method: This case-control and cross-sectional study assessed renal function in Sudanese male patients with essential hypertension. Hypertensive and normotensive subjects were randomly selected. Result: Mean creatinine clearance was 57.8±33.9ml/min in hypertensive cases. Thirty five percent of hypertensive group had >1.5 mg/dl serum creatinine. Urea was found significantly high in 25.8% of hypertensive cases and coincided with those having serum creatinine> 1.7 mg/dl. Mean uric acid was 7.71 mg/dl and 6.03 mg/dl in hypertensive and normotensive subjects respectively. Serum sodium increased in hypertensive cases insignificantly; potassium elevated in 21.2% and 4.2% in hypertensive and normotensive subjects respectively. Albuminuria, casts and RBCs were present in urine of hypertensive patients. Conclusion: Serum uric acid may be a more sensitive test for renal function. Strong association was found between essential hypertension and renal biomarkers.

Keywords: RFT, Sudanese, hypertension.