( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Munilakshmi U., Dr. Shashidhar K. N.*, Dr. Muninarayana C., Dr. Madhavi Reddy and Dr. Lakshmaiah V.


Background: Diabetes is a risk factor for developing Acute Kidney Injury (AKI) in which oxidative stress and inflammation are characteristic features. Methods: Case control prospective study. Subjects were categorized into two groups; Group I: Type 2 Diabetes Mellitus (T2DM) without AKI and Group II: T2DM with AKI. Group II further sub classified into five groups based on Risk, Injury, Failure, Loss and End stage (RIFLE) criteria. Parameters estimated were serum NGAL (Neutrophil Gelatinase Associated Lipocalin) by ELISA (Biovendor, USA), Serum creatinine (Scr), Uric Acid (UA), high sensitive C - reactive protein (hs-CRP), Nitric oxide (NO), Malondialdehyde (MDA), vitamin C and Glutathione peroxidase (GPx) by Spectrophotometric assays. eGFR calculated by Modification of Diet in Renal Disease (MDRD) equation. Results: In Group II NGAL, Scr, MDA, NO, hs-CRP and UA showed a significant elevation while eGFR, Vitamin C, and GPx concentrations were statistically significant in Group I. In Group II as per RIFLE classification NGAL, Scr and NO were significantly elevated in all the subgroups. Conclusion: An imbalance between oxidants and antioxidants were seen in both Groups I and II. So estimation of these parameters in early stages may reduce morbidity rate and prevent risk of AKI in T2DM. In addition to a clinical examination, estimation of MDA and Vitamin C can serve as supportive biochemical markers for early diagnosis and therapeutic intervention.

Keywords: Acute kidney Injury, RIFLE, Malondialdehyde, Nitric oxide, hs-CRP.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on


    DECEMBER Issue has been successfully launched on 1 December 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )