EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CLINICOPATHOLOGICAL CORRELATION OF NON-HODGKIN LYMPHOMA AN IMMUNOHISTOCHEMICAL PROFILE

Nafisa Awadh Mansoor* and Sultan Al-Kubati

ABSTRACT

Introduction: Non-Hodgkin lymphomas (NHL) are assorted group of malignant lymphoproliferative disorder and showing distinctive patterns of behavior and responses to treatment. Objectives: The study aims to assess the diagnostic role of immunohistochemistry for immunophenotyping of non-Hodgkin lymphoma into B-cell and T –cell phenotypes, and to correlate them with age, sex and site of biopsy. Methods: A total of 40 cases of NHL were collected during two years 2012-2013.H&E, IHC were done. The markers used in this study were LCA, CD20, CD3, Ki67, CD10, CD15, CD30, EMA, Bcl2, TdT, CD5, CD34, using En Vision system. Results: 22 cases were males (55%) and 18 cases were females (45%), M: F ratio 1.2:1, age range 2-85. B-cell lymphomas were (87.5%), T-cell lymphomas were (7.5%), unclassified (5%). The most common type of NHL B-cell type was DLBCL (32.5%), followed by Burkitt lymphoma (12.5%), follicular lymphoma (7.5%), MZL (7.5%), B-cell lymphoma unclassified (5%). T-cell lymphomas were three, Precursor T- lymphoblastic lymphoma, T-cell lymphoma (unspecified), anaplastic large cell lymphoma. Two cases were unclassified. The major affected age group was 45-59 (37.5%). Nodal and extranodal were equally affected 50% each. The most common nodal site were cervical lymph nodes (20%). The most common extranodal site were the GIT (17.5%). Conclusions: We concluded that IHC is a very important investigation for all lymphomas and for immunotherapy. IHC is also important for differential diagnosis with other malignancies. B-cell lymphomas outnumber T-cell lymphomas, the most common type of B-cell NHL was diffuse large B-cell lymphoma (DLBCL), followed by Burkitt lymphoma. B-cell lymphoma most commonly nodal with cervical predominant. All T-cell lymphomas were extranodal.

Keywords: Non-Hodgkin lymphoma, immunophenotyping, Yemen.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia