EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ANTI-OXIDANT AND ANTI-BUTYRYLCHOLINESTERASE ACTIVITY OF AN ETHANOLIC EXTRACT OF TINOSPORA CORDIFOLIA.

Suresh Kumar* and Swati Sharma

ABSTRACT

Cholinesterase inhibitors are the most sought after drugs for the symptomatic treatment of Alzheimer‟s disease. The present study, assessed the anti-oxidant and anti-butyrylcholinesterase property of an ethanolic extract of Tinospora cordifolia’s stem, which is an Ayurvedic plant traditionally used for its several medicinal properties. Our findings demonstrated that an ethanolic extract of Tinospora cordifolia’s stem significantly inhibited butyrylcholinesterase enzyme and showed maximum inhibition of 73.59±0.02% at 200μg/ml final concentration with IC50 value of 37.41 μg/mL calculated from the percentage inhibition curve. The mechanism of enzyme inhibition demonstrated by Lineweaver-Burk plot showed competitive inhibition at higher concentration and mixed non-competitive mode of inhibition at lower concentration of plant extract. Antioxidant activity of the extract was assessed by Trolox equivalent antioxidant capacity assay and Ferric reducing ability of plasma assay, which suggested that this plant also possesses significant antioxidant property. The maximum ferrous sulphate equivalent and trolox equivalent values were found to be 1785.66 ± 0.060 μmol Fe2+ E/g of dried sample and 0.72 ± 0.003 mmol Trolox E/g of dried sample respectively. It is concluded that this plant has potential in deriving lead compound for anti-butyrylcholinesterase and antioxidant property which might be beneficial in future for providing symptomatic relief for AD patients.

Keywords: Alzheimer?s disease, Butyrylcholinesterase, Tinospora cordifolia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia