EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND CHARECTERIZATION OF ETHYLCELLULOSE MICROSPHERES OF AN ANTI VIRAL DRUG

M. Sreelatha*, R. Swapna, B. Vishnu Vardhanbabu, SK. Saira Banoo, Y. L. Swarupa, P. Anjaneyulu, P. Rajesh

ABSTRACT

Acyclovir (ACV), a synthetic analogue of 2’-deoxiguanosine, is one of the most effective and selective agents against viruses of the herpes group. Acyclovir microspheres were prepared by multiple emulsion solvent evaporation method, where DCM is used as a solvent for polymer ethylcellulose. PVA (emulsifying agent) is added to external aqueous phase, total of 8 batches are prepared by and evaluated for various parameters. Drug-excipients compatibility was performed by FTIR study. The average particle size of acyclovir loaded microspheres was found in range of 7.75-16.84 μm. Entrapment efficiency of drug loaded microspheres was found in range of 54.68-83.04%. The SEM of acyclovir loaded microspheres showed that the microspheres to be porous and spherical in shape, and also confirm the size of microspheres. Compatibility studies showed that acyclovir was compatible with ethylcellulose. The FTIR spectrum of physical mixture of drug and ethylcellulose, and drug loaded microspheres showed summation of peaks of drug and ethylcellulose. The in vitro release of optimized batch (F5) of drug loaded microspheres was found to be 86.1%. Higher correlation coefficient was observed in the Higuchi plot, indicating that the drug release from ethylcellulose microspheres was diffusion controlled.

Keywords: Acyclovir, Microspheres, Ethyl cellulose.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )