EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

INCIDENCE AND OUTCOME OF ACUTE RENAL FAILURE IN NEONATES WITH PERINATAL ASPHYXIA AND ITS CORRELATION WITH APGAR SCORE AND HYPOXIC ISCHEMIC ENCEPHALOPATHY GRADING

*Sandeep Banga, Mukhtiar Singh Pannu, Sahab Ram, Palveen, Showkat Hussain Talli and Harijot Singh Bhattal

ABSTRACT

Background: World Health Organization has defined perinatal asphyxia (PNA) as a “failure to initiate and sustain breathing at birth.” Acute renal failure a recognized complication of birth asphyxia, carries poor immediate prognosis and may result in permanent renal damage in survivors. Objectives: To determine the incidence of Acute Renal Failure in cases of Perinatal Asphyxia and to correlate it with severity of Apgar score and Hypoxic Ischemic Encephalopathy grading. Methods: this study is done on newborns with gestational age >34 weeks having evidence of birth asphyxia based on APGAR scores and renal function assessment done at day 3 of life. Results: among 50 newborns studied, 46 Forty six percent patients had mild PNA where as 42 % patients & 12% patients were having moderate & severe PNA based on APGAR score. ARF was found in 24% cases of PNA with oliguric renal failure (ORF) in 42% and non oliguric renal failure (NORF) in 58% cases. All cases of ARF (100%) had raised blood urea while it was raised only in 8% of non ARF cases. All patients of severe PNA (100%) had ARF whereas only 28% patients of moderate PNA had ARF. None of patients with mild PNA had ARF. Renal USG showed abnormalities in only 2 (4%) asphyxiated newborns. Conclusions: Our results showed a strong relation between severity of PNA and ARF, with no ARF seen in mild PNA.This study showed a linear relationship between incidence of ARF and staging of HIE. Mortality occurred in ORF cases only.

Keywords: Acute Renal failure in newborns, HIE, PNA.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )