PREPARATION AND EVALUATION OF ZIDOVUDINE MUCOADHESIVE MICROSPHERES

G. Santosh Gada, Dr. Y. Anand Kumar* and C. Mallikarjun

ABSTRACT

Zidovudine mucoadhesive microspheres were studied using carbopol, sodium alginate and mucilage obtained from drumstick as mucoadhesive polymers. Microspheres were prepared at 1:2 and 1:3 core coat ratios by conventional orifice-ionic gelation method and are evaluated for drug content, encapsulation efficiency, in vitro wash off test and in vitro drug dissolution. Microspheres were found to be discrete, spherical and free flowing with uniform drug distribution. The encapsulation efficiency increases as the concentration of sodium alginate increases. Microspheres prepared using drumstick mucilage shows maximum drug release over the period of 12hr when compared to microspheres prepared using chitosan and carbopol. The dissolution data were subjected for model fitting using dissolution software PCP DISSO V.3, in each case best fit model was found to be Korsemeyer’s peppas and exponential ‘n’ value was greater than 0.45, indicate the drug release from microspheres was non fickian i.e., swelling followed by erosion mechanism.

Keywords: Zidovudine; Sodium alginate; Carbopol; Drumstick; Chitosan; in vitro dissolution.