NOVEL METHOD OF TASTE MASKING FOR ORO DISPERSIBLE TABLETS FOR AN EXTREMELY BITTER DRUG
*Anupama Diwan, Aparna Tomar, Rupali Kalra and Ajit Jha
The aim of the present study was to formulate orodispersible tablets (ODT) using resins. For masking the bitter taste of drugs, various resins are used like Indion 204, Indion 214, Kyron T 114, Kyron T 134 etc. We have selected Kyron T-114 (ion exchange resin) to mask the bitter taste and formulate an orodispersible tablets using drug resin complex. The prepared tablets were evaluated for the drug content, weight variation, water absorption ratio, wetting time, in vitro disintegration, hardness, friability, thickness uniformity and in vitro dissolution. The results revealed that Kyron T314 showed least disintegration time compare other disintegrant. This research work suggests simple and cost effective method of formulation of ODT with an objective of masking the bitter taste of a model drug API.
Keywords: Orodispersible Tablets ODT, Kyron T114, Direct Compression, Resins.
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