EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARING THE EFFECTS OF INTRAVENOUS CLONIDINE VS INTRAVENOUS DEXMEDATOMIDINE ON PERIOPERATIVE HEMODYNAMICS IN PATIENTS UNDERGOING LUMBAR SPINE SURGERIES

*Dr. Jyoti Petkar, Dr. Prakash Audichya, Dr. Sameer Goyal and Dr. Virendra Sharma

ABSTRACT

Background: Alpha 2 agonists are commonly used as premedication in major surgeries under general anaesthesia and are useful in maintaining intraoperative haemodynamics. There are very few studies comparing of the two alpha2 agonists clonidine and dexmedetomidine. Methods: Sixty patients aged between 18 to 60 years with ASA status I and II, were included in this prospective, double blinded randomized control study. Patients were randomized into 2 group, Group C-Clonidine group and Group D- Dexmedetomidinegroup using computer generated random numbers. Group C patients received Inj. Clonidine 2 mcg/kg diluted in 10 ml distilled water intravenously and Group D patients received Inj. Dexmedetomidine 1mcg/kg diluted in 10 ml distilled water slow i.v over 10 min. Baseline, intra-operative and post-operative haemodynamics were noted. Post-op seation score and intra-operative blood loss was noted. Results: HR and MAP after induction and after intubation and 2, 4, 6 min post intubation, there was minimal changes seen in Group D as compared to Group C. Post-op sedation score was lower in Group D(0.07±0.06) as compared to group C (1.91±0.03) as observed in post-op recovery room. Conclusion: Dexmedetomidine is more effective than clonidine in attenuating hemodynamic response during laryngoscopy and maintaining intraoperative and post-operative hemodynamics with minimal post-operative sedation and can be effectively used in spine surgeries operated under general anaesthesia.

Keywords: Dexmedetomidine, haemodynamics, anaesthesia.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )