COMPARING THE EFFECTS OF INTRAVENOUS CLONIDINE VS INTRAVENOUS DEXMEDATOMIDINE ON PERIOPERATIVE HEMODYNAMICS IN PATIENTS UNDERGOING LUMBAR SPINE SURGERIES

*Dr. Jyoti Petkar, Dr. Prakash Audichya, Dr. Sameer Goyal and Dr. Virendra Sharma

ABSTRACT

Background: Alpha 2 agonists are commonly used as premedication in major surgeries under general anaesthesia and are useful in maintaining intraoperative haemodynamics. There are very few studies comparing of the two alpha2 agonists clonidine and dexmedetomidine. Methods: Sixty patients aged between 18 to 60 years with ASA status I and II, were included in this prospective, double blinded randomized control study. Patients were randomized into 2 group, Group C-Clonidine group and Group D- Dexmedetomidinegroup using computer generated random numbers. Group C patients received Inj. Clonidine 2 mcg/kg diluted in 10 ml distilled water intravenously and Group D patients received Inj. Dexmedetomidine 1mcg/kg diluted in 10 ml distilled water slow i.v over 10 min. Baseline, intra-operative and post-operative haemodynamics were noted. Post-op seation score and intra-operative blood loss was noted. Results: HR and MAP after induction and after intubation and 2, 4, 6 min post intubation, there was minimal changes seen in Group D as compared to Group C. Post-op sedation score was lower in Group D(0.07±0.06) as compared to group C (1.91±0.03) as observed in post-op recovery room. Conclusion: Dexmedetomidine is more effective than clonidine in attenuating hemodynamic response during laryngoscopy and maintaining intraoperative and post-operative hemodynamics with minimal post-operative sedation and can be effectively used in spine surgeries operated under general anaesthesia.

Keywords: Dexmedetomidine, haemodynamics, anaesthesia.