BILAYER TABLET- A COMPREHENSIVE REVIEW
M. D. Bhosale* and K. S. Kulkarni
ABSTRACT
From last decade, over 90% drugs are manufactured in the form of oral dosage form. This shows that oral dosage form gained attention now a day and become popular class of formulation worldwide. Conventional oral dosage form showing number of disadvantages i.e. mainly high frequency of dosing and dose. For overcome this problem there is increased interest in developing controlled drug delivery. Bilayer tablet is successful new era for development of controlled release formulation. Bilayer tablet technology, an excellent improved technique for providing combine release pattern of drug i.e. immediate release and sustained release. In this system two incompatible drugs combined together in single dosage form. There are different approaches available for bilayer tablet technique. Biphasic system formulated with drug having analgesics, antipyretics, antiallergenic, coronary vasodilators, antihypertensive and antihistaminic activity. Now a day several companies come in competition for development of bilayer tablet for number of reasons- patent extension, therapeutic, marketing to name a few.
Keywords: Bilayer tablet, GMP requirement for bi-layer tablets, various tablet presses, Approaches.
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