( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Abdullah Ali Yahya AL-Asali, Dhia Eldin Elhag and Abutalib Alamin


Objective: To assess the stability of Bisoprolol Fumarate under different stress conditions. Methods: Different samples of Bisoprolol Fumarate standard were subjected to a variety of stress conditions as a temperature, a combination of temperature and relative humidity, direct sunlight, acid/base hydrolysis, and oxidation were subsequently analysed. The analysis was carried out using RPHPLC system equipped with UV/vis detector. Results: Bisoprolol Fumarate was stable in diluent when exposed for 72 hrs (at room temperature). The results of analysis showed that the drug standard was 99.50% which proves that no degradation. When the drug was subjected to 75ºC for 6 hours (Dry Temperature), there was no change in drug potency. No change in the assay content when Bisoprolol Fumarate was exposed to a temperature of 105ºC for one hour. Upon exposure to sunlight in a temperature recorded between (35-40ºC) for 72 hours, Bisoprolol Fumarate was unstable, the drug content decreased to 95.73%. The effect of heat and relative humidity was a decreased in drug assay (i.e. from 99.69% to 93.78%) for one month. Bisoprolol Fumarate was affected by acid and base hydrolysis (0.1M), the drug content was decreased from 99.96% to 94.72% and 91.60% respectively. Moreover, the drug was affected by oxidation (30% H2O2) and the drug content decreased from 99. 96 % to 96.91%. Conclusion: Bisoprolol Fumarate stability was effected when exposed to different stress conditions.

Keywords: Stability, Bisoprolol Fumarate, Stress conditions.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on


    NOVEMBER Issue has been successfully launched on 1 November 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )