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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Eluwa Mokutima Amarachi*, Anyam Gerrard Teryil, Asuquo Olaitan Ruth, Isamoh Theresa Ekpenyong, Udonkang Mfoniso Iniobong and Ekanem Theresa Bassey


Aspilia Africana is one of the major herbs being used by many Nigerians to treat many ailment such as; wound healing, stoppage of bleeding, cough, gonorrhoea, feverish headache, stomach troubles and also help in easy delivery and lactation. This study was to examine the teratogenicity of aqueous leaf extract of Aspilia Africana on frontal cortex of foetal wistar rats. Twenty adult female rats weighing between 190 - 205g were used for this study. The rats were divided into four groups labelled control, low dose, medium dose and high dose, with each consisting of five rats. Pregnancy was induced by caging the female rats with sexually matured males. The presence of vaginal plug and tail structures in the vaginal smear the following morning confirmed coitus and was regarded as day zero (0) of pregnancy. Control group was given distilled water. Low dose, medium dose and high dose groups received 750mg, 1000mg and 1250mg of aqueous leaf extract of Aspilia Africana per kilogram body weight orally with the aid of orogastric tube respectively on days 7-11 of gestation. On the day 20 of gestation, the rats were sacrificed and the foetal brain was fixed in formal saline and later processed for histological studies. Histological observations of the frontal cortex showed hyperplasia and hypertrophy especially in the subventricular and ventricular layers of the low dose. Distortion of cortical, intermediate and subventricular layers of the medium dose group; and complete distortion of the layers of the frontal cortex in the high dose group characterised by numerous vacuolations and cellular degenerations. Blood vessels appeared tiny and almost absent in all the treated groups. The result suggest that aqueous leaf extract of Aspilia Africana may be teratogenic to the developing frontal cortex of wistar rats and is dose dependent.

Keywords: Teratogenicity, Aspilia africana, aqueous extract, frontal cortex, foetuses.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )