( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Dr. Abdel-Aziz Yehya*, Ibrahim Gamaan, Mohamad Mahfouz and Refaat Ibrahem


Background/Aim: It is crucial to exactly identify the level of transition to the normal ganglionic colon in instances of Hirschprung's disease (HD). The correlation between the laparoscopic leveling of the transitional zone (TZ) and frozen section histopathologically based level of aganglionosis has not been well studied. The aim of this study is to assess whether the laparoscopic leveling of TZ could be a reliable method for the diagnosis of the actual level ofaganglionosis of the HD. Patients and Methods: The study included 150 patients’ diagnosedas HD by rectal biopsy. All patients were subject to laparoscopy for identification of TZ. Three laparoscopic seromuscularbiopsies was taken for intra-operative frozen section [IOFS] from thelaparoscopically identified TZ, 2-cm distal and 10-cm proximal to TZ. In cases of non-identification of any TZ, laparoscopic seromuscular biopsies were taken from therectosigmoid, sigmoid, descending colon, splenic flexure and the transverse colon for IOFS. Then, laparoscopic assisted endo-rectal pull through was completed according to the results of IOFS. The results of IOFS were compared with the results of permanent paraffin section Results: The study included 98 males and 52 females with HD. Their mean age was 2.4±12 years (age range = 5 months to 6 years). All operations were completed laparoscopically without conversion. The mean operative time was 54.4±12 minutes (range =45 to 70 minutes). Laparoscopic identification of the TZ coincided with the suspected TZ in the images of preoperative barium enema in 125 patients. While in 25 patients without a detectable TZ in the preoperative barium enema, TZ was identified laparoscopically. Laparoscopic identification of the level of the TZ zone coincided with thehistopathological results of IOFS [IOFS] and permanent paraffin section in all patients. No intraoperative complications were reported. Conclusion: Laparoscopic identification of TZ in patients with HD is a feasible and a safe procedure. It is a reliable method for determining the actual level of aganglionosis in HD.

Keywords: Laparoscopy, Frozen section, Biopsy, Hirschsprung`s disease. Leveling colostomy. Transitional Zone.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on


    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )