DESIGN, SYNTHESIS & PHARMACOLOGICAL EVALUATION OF NEW SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTIULCER, ANTISECRETORY & ANTICONVULSANT AGENT
Khan Farhan R.*
ABSTRACT
The present research study was designed to investigate the effect of 2-(pyrimidinylsulfinyl)benzimidazole derivative experimentally tested as Antiulcer & Antisecretory Agents. Aspirin-induced gastric ulcer model was used for Antiulcer Activity by using ulcer inducing agents, i.e acetylsalicylic acid and indomethacin screening model in Wistar rats and compound were also assayed on gastric acid secretion of animals, acute models of gastric mucosal lesions for gastric H+/K+- ATPase inhibition. The second series derivatives of 2-Amino benzimidazole experimentally tested as Anticonvulsant Activities. The pharmacological screening protocol for the anticonvulsant activity of the synthesized compound was checked by electroshock method. various degrees of inhibitions by 2- (pyrimidinylsulfinyl) benzimidazole & 2-Amino benzimidazole derivative (50-200 mg/kg/p.o) were statistically significant (p<0.001). The effect of several benzimidazole synthesized compound were compared to that of the standard drugs used.
Keywords: 2-Pyrimidinylsulfinyl Benzimidazole, 2-Amino Benzimidazole derivative, Antiulcer, Antisecretory, Anticonvulsant activities.
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