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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Dr. Pinaki Mukhopadhyay, Dr. Pragateshnu Das and Dr. Gautam Guha


Aims and Objective: To study the spectrum of movement disorder in chronic kidney disease patients and the clinical and laboratory parameter of various movement disorders. Also to correlate the severity of parkinsonism according to modified UPDRS score with estimated glomerular filtration rate. Lastly, to compare features of parkinsonism in CKD patients with those of idiopathic Parkinson disease. Methodology: Results: The study had a preponderance of male (64%) to female (32%) percentage. Various movement disorder were found namely myoclonus (40%), parkinsonism (50%), rest tremor (8%), bradykinesia (50%), restless leg syndrome (10%), postural tremor (8%). The severity of parkinsonism and eGFR showed negative correlation. Clinical comparison between idiopathic Parkinson disease and CKD patients with parkinsonism showed rest tremor (p value <0.006) being less prevalent, with pyramidal features (p<0.001), gait abnormality (p<0.006) more prevalent. Comorbidity like diabetes (p<0.04) more common in CKD parkinsonism patients. Imaging study showed white matter hyperintensity (p<0.001) more common in CKD. CKD patients were less responsive to levodopa (p<0.001). Conclusion: The spectrum of movement disorder seen in patients with chronic kidney disease is quite varied. It spans from cortical disorder like myoclonus to basal ganglia disorder like parkinsonism. The severity of Parkinsonism has no correlation with eGFR. Pyramidal sign and gait problem were more common in CKD patient with parkinsonism and rest tremor is less common. Comorbidity like hypertension and diabetes mellitus are more common in parkinsonism patients with CKD than those without. Imaging abnormality is more common in CKD patients. White matter hyperintensity being most common. CKD patients are also less responsive to levodopa therapy.

Keywords: Movement disorder, Chronic kidney disease, Parkinsonism, India.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database