EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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Abstract

AMELIORATION OF MERCURIC CHLORIDE AND RADIATION INDUCED HISTOPATHOLOGY IN MICE BY MORINGA OLEIFERA

Jayshree Banot, R. K. Purohit*, Manoj Kumar Bana, Manisha Agarwal and Aruna Chakrawarti

ABSTRACT

The aim of the present study was to investigate the impact of the Moringa oleifera against combined administration of mercuric chloride and radiation on histopathological changes in the liver of mice. The mice were exposed to mercuric chloride (0.5ppm) and gamma radiation (5.0Gy) simultaneously and individually. The experimental groups were given Moringa oleifera seven days prior to radiation or mercuric chloride treatment. The changes included cytoplasmic degranulation, vacuolation, nuclear pycnosis, necrosis, hyperaemia and leucocytic infiltration etc. In the combined treatment groups the changes were more severe showing synergistic effect. An early and fast recovery in Moringa pre treated groups may be due to the protection provided by the drug.

Keywords: Moringa oleifera, nuclear pycnosis, necrosis, hyperaemia and leucocytic.


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SJIF Impact Factor: 7.065

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