EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

URINARY 8-OHDG (8-HYDROXY-2? -DEOXYGUANOSINE) AS BIOMARKER OF CANCER INDUCED OXIDATIVE DNA DAMAGE

Deependra Singh Raghuwanshi and *Reddy P. B.

ABSTRACT

Cancer induced oxidative DNA damage is subject of interest today. The oxidized bases like 8-hydroxy-2’-deoxyguanosine are formed due to DNA damage which is continuously excreted through urine. 8-OHdG (8-hydroxy-2′ -deoxyguanosine) is one of the major forms of free radical-induced oxidative cuts, and for that reason it has been extensively used as a biomarker for oxidative stress and carcinogenesis. The present study was intended to assess the oxidative DNA damage in lung cancer patients by using a urinary 8-OHdG as biomarker. A case study was carried out on 18 lung cancer patients (12 men and 6 women) who were undergoing chemotherapy. Patients were identified on the basis of various hospital records. Urinary 8-OHdG levels of lung cancer patients were estimated by enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody. Eighteen urine samples of pulmonary cancer patients were collected in and around Nagda town (Ujjain, M.P.India) and were examined for 8-oxo-2′-deoxyguanosine by ELISA technique. The urinary 8-OHdG levels in lung cancer patients were significantly higher than in control (119.48 ± 13.14 ng/ml versus 5782.2 ± 195.3 ng/ml). We conclude that estimation of urinary 8-OHdG is easy and useful biomarker for the diagnosis of cancer induced DNA damage. In our opinion a follow-up of urinary 8-OHdG might be a useful future tool for the evaluation of DNA damage.

Keywords: Reactive oxygen species (ROS), 8-Hydroxydeoxyguanosine (8-OHdG), ELISA, Lung cancer.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia