EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICAL CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF BRIDELIA RETUSA BARK SPRENG. IN ACUTE AND CHRONIC INFLAMMATORY CONDITIONS: A POSSIBLE MECHANISM OF ACTION

Dr. Anil Tatiya*, Dr. Ajay Saluja, Dr. Mohan Kalaskar, Dr.Sanjay Surana and Dr. Prakash Patil

ABSTRACT

Several species of Bridelia have been used to relieve pain in arthritic condition (rheumatic pain) in Indian folk medicine. This study was designed to explore the preliminary phytochemical analysis of Bridelia retusa spreng. (Euphorbiaceae) and further evaluation of its analgesic, anti-inflammatory and anti-arthritic activity as well as underlying mechanism of fraction in rats. Bridelia retusa spreng bark was extracted using pet.ether,ethyl acetate and acetone. All the extracts were significantly inhibit abdominal writhings response of mice and inhibit licking time in late phase by inducing formalin. Test samples could also significantly inhibit mean paw edema of rats induced by carrageenan & histamine at dose of 200 & 400 mg/kg, ip. Test materials also showed significant dose dependent reduction in cotton pellet granuloma & acetic acid induced vascular permeability at 400 mg/kg. In FCA induced arthritic rats, physical changes, biochemical and hematological parameters observed in arthritic animals were altered significantly to near normal condition after oral administration of Bridelia retusa fractions. The maximum paw edema inhibition at day 21 was observed at 400 mg/kg. It also proved significant protection against protein denaturation & RBC membrane damage. The GC-MS analysis of EA extract revealed the presence of β-sitosterol, stigmasterol, lupeol and friedelin (Pentacyclic triterpenoid). In conclusion, the current study has demonstrated the analgesic; anti-inflammatory and anti-arthritic activities of Bridelia retusa bark fractions and suggested that the molecular membrane might be associated with inhibition of biochemical and hematological parameters. Overall bioactive profile of Bridelia retusa makes it an attractive candidate for future development as a drug or phytomedicine.

Keywords: Bridelia retusa Spreng. Lupeol, Anti-inflammatory; Freund’s complete adjuvant; Euphorbiaceae; Protein denaturation; Leukocyte migration.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )