EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A COMPARATIVE STUDY AND PHYTOCHEMICAL SCREENING, DPPH FREE RADICAL SCAVENGING AND IN-VITRO STUDY OF CYTOTOXIC ACTIVITY OF ANDROGRAPHIS PANNICULATE AND LEUCAS ASPERA ON MA104.

Ponnambalam Arun*, Kaveri Krishnasami, Palani Gunasekeran, Vidya Padmanabhan

ABSTRACT

Objective: To investigate the phytochemical, cytotoxicity, antioxidant activity of whole Leucas aspera and Andrographis panniculate alcoholic extract on MA104 cells in-vitro using MTT. Methods: Andrographis panniculate and Leucas aspera was extracted by absolute ethanol, chloroform, acetone and water. This extract was subjected to phytochemical screening (qualitative), followed by analysis for antioxidant activity (DPPH assay) and ethanol extract was used to investigate the cytotoxic activity of the A.panniculate and L.aspera by in-vitro using 3‐(4, 5‐dimethyl thiazol‐2yl)‐2,5‐diphenyl tetrazolium bromide (MTT). Results: Crude ethanolic extract of plant Leucas aspera and chloroform extract of Andrographis panniculate showed to be having antioxidant activity with IC50 value of 4.45μg/ml while compared with control ascorbic acid which had an IC50 value of 13.5μg/ml. The potency of the plant extract concentration has been calculated using percent decrease in number of viable cells in MA104 compared with control value. Conclusion: Based on the crude extract results obtained indicates the presence of phenolic compounds that serves as free radical may be a promising drug candidate that could be used in drug designing for diarrheal and various pharmacologic activities and presence of tumorigenic property indicates it can also be used as candidate to treat cancer after screening of the pure compound in the plant.

Keywords: Phytochemicals, Leucas aspera, Andrographis panniculate, DPPH, MA104, Cytotoxicity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )