EFFECTIVE NOVEL PHARMACEUTICAL TECHNOLOGIES FOR BRAIN DRUG DELIVERY SYSTEMS: AN REVIEW

Ch. Tarakaramarao*

ABSTRACT

The regulated entry of most blood-borne substances into the brain has been recognized for more than a century. The blood-brain barrier shielding function provided by endothelial cells is important in the treatment of neurological diseases because this exclusion of foreign substances also restricts entry of many potentially therapeutic agents into the brain. BBB allows a selective entry of nutrients and minerals across it and limits the entry of foreign substances like drugs as well as neuro pharmaceutical agents. The conventional drug delivery systems which release drug into general circulation fail to deliver drugs effectively to brain and is therefore not very useful in treating certain diseases that affect CNS including Alzheimer’s disease, dementia, Parkinson’s disease, mood disorder, AIDS, viral and bacterial meningitis. The various strategies available and under development for enhancing drug delivery to the CNS are reviewed. The present review enlightens about several novel approaches including nanotechnology based approach like nanoparticles, liposomes, antibody mediated delivery approach and application of genomics in brain drug targeting that would give an insight to the researchers, academia and industrialists.

Keywords: BBB, Nanoparticle, Liposomes, Chimeric peptides, Mannitol.