SYNTHESIS OF SUBSTITUTED PYRIMIDINE DERIVATIVES AND ITS ANTIBACTERIAL ACTIVITY

S. Singh*, Dr. Shamim Ahmad and Dr. Shamsher Alam

ABSTRACT

A novel series of substituted Pyrimidine derivatives have been synthesized from substituted acetophenone with appropriate quantity of substituted aromatic aldehyde in presence of aqueous alcoholic alkali was used for formation of α, β – unsaturated ketones (i.e. chalcones). Equimolar portions of the substituted acetophenone (10mmol, 1 equiv) and substituted benzaldehyde (10mmol, 1 equiv) were dissolved in 15ml of ethanol and recrystallized from ethanol to give chalcone derivatives (I). To chalcone (10mmol) obtained from step 1, added guanidine nitrate then reflux for 2 hr The precipitate formed washed with cold water until it turns neutral to pH paper, filtered and recrystallized from ethanol to give derivatives (II). To mixture of derivatives (II) (10mmol), 1,3-dichloroethane (10mmol) and 25% NaOH (0.025 mol, 10 ml) was refluxed in methanol(25 ml) for 8-12 h. The resulting mixture (III) was poured into ice-water and stirred. The crude product Pyrimidine were separated and recrystallized from Acetone.

Keywords: Antibacterial activity, Antifungal activity, Pyrimidine etc.