DOCKING, SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 2-ALKYL SUBSTITUTED 1-(PYRIDIN-3-YL) METHANONE OXIME BENZIMIDAZOLE DERIVATIVES

Singh Jitender*, Sethi Reeta, Wasil Preeti and Madaan Shyna

ABSTRACT

A series of 2-substituted-benzimidazolyl-(pyridin-3-yl)-methanone oximes (11-15) were synthesized and tested for in vivo anti-inflammatory activity using carrageenan induced paw edema in rats. The compounds were also subjected to docking studies which indicated the importance of interactions of COX-2 receptor with synthesized derivatives. The results of docking studies and in vivo activity were same as and indicated compound 15 to be most active. Hence, benzimidazole nucleus can play a significant role in treatment and prevention of inflammatory disorders.

Keywords: Benzimidazole; Synthesis; Anti-inflammatory; Docking; Cyclooxygenase.