EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FLURBIPROFEN OPHTHALMIC SOLUTIONS TARGETING THE POSTERIOR SEGMENT OF EYE: AN EX-VIVO STUDY AND A NOVEL PRODRUG APPROACH ON EXCISED GOAT CORNEA

Ugandar R. E.*, Dinesh Kumar Sharma, Kiran C. Nilugal and Nagashekhara Molugulu

ABSTRACT

The current research involves the study of enhancement of trans-corneal permeation Non- Steroidal Anti-Inflammatory Drug, Flurbiprofen via amino acid transporters through excised goat cornea. The prodrug approach by esterification of amino acids followed by conjugation of the amino acid esters with the drug through solvent evaporation technique has been adopted for the synthesis of the physical mixtures of esterified amino acids conjugated with Flurbiprofen. The physical mixtures obtained were characterized by several analytical techniques, purified and were used as active ingredients for preparing the test formulations of Flurbiprofen. In the study, three categories of conjugated physical mixtures of Flurbiprofen with three different amino acids such as L-Arginine, L-Tyrosine and L- valine were synthesized initially by esterification of the amino acids to get methyl and ethyl esters of the amino acids followed by conjugation with Flurbiprofen. The purified products were used as active ingredients for different test formulations of Flurbiprofen. The results obtained from the trans-corneal permeation studies on excised goat cornea during the ex-vivo studies by using a Franz diffusion cell were compared with those of the standard ophthalmic formulations of Flurbiprofen. All results revealed that the permeation of drugs with the amino acid transporters were found to be enhanced through excised goat cornea when compared with the results of the prepared standard formulation of Flurbiprofen.

Keywords: Flurbiprofen, pro-drug, permeation, ex-vivo, diffusion, & amino acid transporters.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )