EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF ETHANOLIC EXTRACT OF TINOSPORA CORDIFOLIA ON OXIDATIVE STRESS INDUCED BY CEREBRAL ISCHEMIA-REPERFUSION IN RATS

Anshuman Trigunayat* and Shardendu Kumar Mishra

ABSTRACT

Restoration of blood flow to ischemic brain is linked with generation of reactive oxygen species. In Ayurveda, the medicinal properties of Tinospora cordifolia have been attributed to its anti-stress, antioxidant, neuroprotective, adaptogeneic and nootropic properties. The present study investigates the effect of ethanolic extract of T. cordifolia on acute cerebral ischemia-reperfusion in rats. Acute cerebral ischemia-reperfusion (30 min occlusion of bilateral common carotid arteries followed by 45 min reperfusion) in Charles Foster (C.F.) strain rats was produced following standard technique. Effect of Tinospora cordifolia on lipid peroxidation, superoxide dismutase (SOD) activity, ascorbic acid, cyclic AMP level and total tissue sulfhydryl (T-SH) group in for brain region in acute cerebral ischemia-reperfusion were evaluated. T. cordifolia pre-treatment (100 mg/kg p.o. for 7 days) attenuated the reperfusion induced biochemical alterations. The results suggest protective role of T. cordifolia in cerebral ischemia reperfusion injury.

Keywords: Ischemia, Reperfusion injury, Oxidative stress, Neuroprotection, Tinospor.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )