EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CYPERUS ROTUNDUS EXTRACT EXERTS ANTICANCER ACTIVITY ON EHRLICH ASCITES CARCINOMA

Hema Nidugala*, Ramakrishna Avadhani, Ashwini Prabhu and Ravishankar B.

ABSTRACT

Introduction: Cancer is one of the most serious health concerns in both developing as well as the developed countries. Despite the advancements in the treatment modalities, mortality rates due to cancer are alarming. Adverse effects of chemotherapy and radiation therapy demands the search for alternative therapies, among which phytotherapy looks promising. Aims and objectives: This study was designed to evaluate the anticancer efficacy of Cyperus rotundus extracts on experimentally induced Ehrlich ascites carcinoma. Materials and Methods: Cyperus rotundus rhizomes were extracted in ethanol and water by maceration method. Ehrlich ascites carcinoma was induced in swiss albino mice by intraperitoneal injection of 2.5x106 cells /mice viable tumor cells. Animals were treated with Cyperus rotundus extract per orally with 250 mg/kg and 500mg/kg body weight dosages. Mean survival time of the animals was recorded and compared with that of tumor control. A subpopulation from all the treatment groups was sacrificed and analyzed for hematological and biochemical parameters as per standard protocols. Results and Conclusion: Cyperus rotundus extract could increase the life span by 36% and 20% in groups treated with 250 mg/kg wt. and 500 mg/kg body wt. respectively. Hematological parameters were restored to normal levels in extract administered groups. Antioxidant activity assay indicated that the extract treatment could increase the levels of antioxidant enzymes. In conclusion, Cyperus rotundus ethanolic extract possessed potent anticancer activity against Ehrlich ascites carcinoma in Mus musculus system.

Keywords: Anticancer, Cyperus rotundus, Mean survival time, Ehrlich ascites carcinoma.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )