EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A PROSPECTIVE STUDY OF PREDICTORS OF MORTALITY IN ACUTE RESPIRATORY FAILURE IN H1N1 INFLUENZA.

Dr. Mahendra M., Dr. Chaya S. K., Dr. Lokesh K. S., Dr. Jayaraj B. S., Dr. Anirudh Kumar and Dr. Mahesh P. A.*

ABSTRACT

Aim: H1N1 pneumonia with respiratory failure is associated with significant mortality and morbidity. There is a need to evaluate independent predictors of mortality. Methodology: Patients with suspected H1N1 pneumonia presenting to emergency at JSS Hospital, Mysuru during February-June 2015 were screened for H1N1. Patients with H1N1 were evaluated for independent predictors of mortality. Survivors were followed up at 3rd month and 1 year for long-term sequelae and activity limitation. Results: 175 patients were screened for H1N1 and 71 were confirmed, of which 52 needed ICU admission and 24 needed mechanical ventilation. Nine subjects were given a trial of NIV before mechanical ventilation. Twenty eight subjects could be managed with NIV alone. A very high mortality 24/71 (33.8%) was observed inspite of anti-viral treatment. Cox regression analysis identified APACHE II score (>10), comorbidities and rise in platelet counts (<15% from baseline) were independently associated with mortality. No long term sequelae or activity limitation was observed in survivors. Conclusion: H1N1 pneumonia with respiratory failure is associated with very high mortality. Each of the above 3 variables APACHE II score (> 10), comorbidities and rise in platelet counts (<15%from baseline) were associated with a greater than 3 times the hazard for mortality.

Keywords: APACHE II, H1N1, Influenza, long-term sequelae, mortality.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )