EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

HAEMORHEOLOGIC AND FIBRINOLYTIC ACTIVITY IN HIV SEROPOSITIVE SUBJECTS AT NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL (NAUTH), NNEWI

Obioma Chinwe F.*, Jeremiah Z. A., Okamgba Okezie and Obeagu Emmanuel Ifeanyi

ABSTRACT

Cardiovascular disease has become a major health challenge among HIV patients especially those on antiretroviral therapy (ART). Haemorheology and fibrinolysis are well-defined cardiovascular risk factors. This study was carried out to provide information on the haemorhelogic and fibrinolytic activity in HIV Patients on ART and those not on ART. Blood sample was collected from 160 subjects, 55 HIV-infected patients on Antiretroviral therapy (ART), 55 HIV-infected patients not on ART and 50 apparently healthy HIV Sero-negative individuals as controls. Euglobulin Lysis Time (ELT), Plasma Viscosity (PV), Plasma Fibrinogen Concentration (PFC), CD4 Count, Haematocrit (HCT) and Retroviral screening (RVS) of the subjects were determined using standard methods after obtaining ethics approval and informed consent of the subjects.. ANOVA and t-test were used for statistical analysis. The results showed that ELT, PV, PFC and RDW were significantly higher in HIV infected patients (F=504.74; 130.40; 41.78; 35.63; P<0.05 respectively) compared with control subjects. CD4 was significantly (p<0.05) lower in HIV patients (F=60.57) compared with control subjects.ELT, PV PFC and RDW were significantly higher (P<0.05) in HIV patients on ART (t=10.25; 5.14; 2.11; 5.20) compared with HIV patients not on ART. This study showed that HIV patients especially those on ART have impaired blood flow and derranged fibrinolytic activity which predispose them to increased cardiovascular risk. Hence integration of routine laboratory analysis of haemorheologic and fibrinolytic parameters into HIV management scheme is recommended for more effective HIV patients’care.

Keywords: Haemorheologic, Fibrinolytic activity, HIV seropositive subjects, Nnewi.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )