EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF MICRORNA-93, MICRORNA-210 IN EGYPTIAN PATIENT WITH POST HCV HEPATOCELLULAR CARCINOMA

Amal Tohamy Abdel Moez*, Mohammed Salah El Din, Nashwa Nayg El Khazragy, Mai Mohamed El said

ABSTRACT

Background: Hepatocellular carcinoma is one of the most highly malignant and lethal cancers of the world. The most urgent needs are to find sensitive markers for early diagnosis for HCC. MicroRNAs are conserved non-coding RNAs which regulate gene expression at the posttranscriptional level. They have been recently identified as important regulators that affect carcinogenesis. This study was conducted to detect the serum MiRNA 210 and MiRNA 93a to be applied as early detectors for HCC. Methods: A total of 60 serum samples (30 samples from HCC patients,15 samples from chronic Hepatitis c virus patients and 15 healthy control ) were collected. The levels of 2 mature miRNAs (miR-210 and miR-93 a) were detected by real time quantitative reverse-transcriptase PCR (RT-qPCR) in sera of the 60 subjects. Results: Results of the present study showed a higher mean baseline miR- 210 level in patients with HCC compared with cirrhotic and control subjects ( HCC, 4.25+ 6.18 ) VS (cirrhotic, 3.14+2.25) VS (control, 1.03+ 0.30),(P < 0.000). Conclusion: In conclusion, The expression of miRNA 210 and miRNA 93a was significantly upregulated in serum of patient with HCC, As a result miRNA 210 and miRNA 93a could be as potential circulating promising noninvasive early detectors for HCC and useful for screening in high risk vulnerable subjects.

Keywords: miRNA 210 and miRNA 93a.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database