ANTIPHOSPHLIPIDS ANTIBODIES IN CHRONIC HEPATITIS B PATIENTS PRESENTING AT A TERTIARY CARE HOSPITAL OF SINDH

Sameeta*, Muhammad Junaid Mahboob, Kiran, Amar Lal,  Poonam Bai

ABSTRACT

Objective: To investigate the antiphospholipid antibodies in chronic hepatitis B patients presenting at a tertiary care hospital of Sindh. Study design: Case control study. Place and Duration: Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro from January 2016 to December 2016. Subjects and Methods: The present study included 100 chronic hepatitis B and 100 controls. Anticardiolipin antibodies IgG, IgM and β2-glycoprotein I IgG and lupus anticoagulant (LA) were detected. Data was analyzed on SPSS 22.0 (IBM, Incorporation, and USA) at 95% confidence interval (P≤ 0.05). Results: Anticardiolipin IgG, anticardiolipin IgM, and β2-Glycoprotein I IgG were noted as 3 and 19%, 2% and 15%, 0% and 37%, & 1% and 7% respectively. Anticardiolipin IgG, IgM, and β2-Glycoprotein I IgG were noted as 10.74±1.61 and 13.80±3.5 U/ml, 11.12±1.50 and 15.32±3.62 U/ml & 132.7±.19 and 206.3±16.8 μg/ml in control and cases respectively (P<0.05). Anticardiolipin IgG showed positive correlation with serum creatinine, PT, APTT, anticardiolipin IgM and β2-Glycoprotein I IgG. Conclusion: In conclusion, the present study found antiphospholipid antibodies anticardiolipin IgG, anticardiolipin IgM, β2-Glycoprotein I IgG and lupus anticoagulant in the hepatitis B infected.

Keywords: Anticardiolipin IgG, Anticardiolipin IgM, ?2-glycoprotein I IgG, Lupus anticoagulant, Hepatitis B virus.