EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

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Abstract

IMMUNOLOGICAL CHARACTERISTICS OF HYPERREACTIVE MALARIAL SPLENOMEGALY SYNDROME

Amar Lal*, Muhammad Junaid Mahboob, Sameeta, Kiran and Sagar

ABSTRACT

Objective: The present study investigated the immunological characteristics of IgM, IFN𝛾 and IL10 cytokines in the hyperreactive malarial splenomegaly syndrome (HMSS) at a tertiary care hospital of Sindh. Study design: Case control study. Study setting & Duration: Department of Medicine- LUMHS Jamshoro, from February 2016 to December 2016. Subjects & Methods: A sample of 60 cases of HMSS and 60 normal subjects were selected as controls. The HMSS cases were diagnosed as by Bates et al criteria. Size of spleen and liver was measured by sonography. Serum IgM, IFN𝛾 and IL10 cytokines were measured. Data saved in a pre structured proforma. Confidentiality was maintained. Software ―Statistix 9.0‖ (USA) was used for statistical analysis at 95% confidence interval (P ≤ 0.05). Results: Immunological markers the IgM, Interferon-𝛾 (IFN𝛾) and Interleukin-10 (IL-10) were found elevated in the HMSS cases (P=0.0001). Spleen size was significantly positively associated with the IgM (r= 0.707, P=0.0001), IFN𝛾 (r= 0.70, P=0.0001) and IL-10 (r= 0.826, P=0.0001) and liver span (r= 0.821, P=0.0001). Conclusion: The present study noted elevated IgM, IFN𝛾 and IL-10 cytokines levels in the hyperreactive malarial splenomegaly syndrome.

Keywords: IgM, IFN????, IL-10, Hyperreactive malarial splenomegaly syndrome.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia