ASSOCIATION OF GAMMA GLUTAMYL TRANSFERASE AND BLOOD LIPID LEVELS IN TYPE 2 DIABETIC SUBJECTS

Poonam Bai*, Fnu Sandeep, Sateesh Kumar, Sheena Shiwlani, Roopa Kumari and Jitesh Kumar

ABSTRACT

Objective: The present study analyzed the correlation of ϒ-glutamyl transferase (GGT) with the high density lipoprotein and low density lipoprotein in type 2 diabetics. Study Design: Case control study. Study setting & Duration: Department of Medicine- LUMHS Jamshoro, from January 2016 to September 2016. Subjects & Methods: 100 type 2 diabetics and 100 controls were selected through non-probability (purposive) sampling. Clinical history, physical examination and blood biochemical findings were noted in proforma. Biochemical tests were performed as per standard criteria on Roche Hitachi Chemistry Analyzer. GGT was detected by IFCC method. Data was analyzed at 95% confidence interval on the statistical package SPSS 22.0 (IBM, Incorporation, USA) and Microsoft excel. Results: The GGT was noted as 20.44±5.71 and 39.5± 5.56 U/L (P=0.0001) and the HDLc as 49.15±3.67 and 30.19± 10.61 U/L in controls and cases respectively (P=0.0001). GGT showed positive correlation with systolic BP, diastolic BP, blood glucose, HbA1c, creatinine, cholesterol, triglycerides and LDLc. Negative correlation was found of GGT with the HDLc (r= - 0.676, P=0.0001). Conclusion: The present study found negative correlation of GGT with HDLc but positive correlation with LDLc. Hence, the GGT may be exploited as a simple and inexpensive atherogenic biomarker instead of expensive lipid profile.

Keywords: Gamma-Glutamyl Transferase, HDLc, LDLc, Diabetes Mellitus.