A REVIEW ON THIRD GENERATION CEPHALOSPORINS

Asma Riaz* and Marriam Zaka

ABSTRACT

Rational use of drugs refers as patients receive medicines according to their clinical needs at lowest cost. The beta lactam antibiotics alter cell wall biosynthesis. Cephalosporins belong to beta lactam antibiotics and classified into 1st, 2nd, 3rd, and 4th generation. If huge number of organisms are involved in diseases then generation wise cephalosporins are used. The beta lactam antibiotics are commonly used to cure after operation wounds due to its extended spectrum of activity and clinical effectiveness and high safety profile. The third- generation cephalosporins are widely used antibiotics in both males and females for treatment of different diseases and have lesser side effects as compared to aminoglycosides and polymixins. For Enterobacter aerogenes the magnitude of susceptibality to third generation cephalosproins is higher than amikacin. Ceftriaxone is widely used third generation cephalosporins. Cefotaxime shows the effectiveness in uncomplicated urinary tract infection. Patients who are allergic to penicillins have more chances of adverse drug reactions to cephalosporins. Third generation cephalosporins show extensive resistance due to overutilization and improper utilization. The danger of third generation cephalosporins resistance was especially high in nosocomially-produced scenes of unconstrained bacterial peritonitis. There should be consistent surveillance, investigation and efforts to deal with resistance related problems.

Keywords: Third-generation cephalosporins, Utilization, Resistance, Surveillance.