EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NON–ST-ELEVATION MYOCARDIAL INFARCTION (NSTEMI) OUTCOMES IN TYPE 2 DIABETIC PATIENTS WITH NON-OBSTRUCTIVE CORONARY ARTERY STENOSIS: DIABETIC MYOCARDIAL INFARCTION CORONARY NON-OBSTRUCTIVE STENOSIS: DIA-MYCONOS STUDY.

Raffaele Marfella, MD, Phd, Celestino Sardu, MD, Msc, PhD*, Maria Luisa Balestrieri, PhD, Mario Siniscalchi, MD, PhD, Antonino Coppola, MD, Fabio Minicucci, MD, Pasquale Paolisso, MD, Davide D’Andrea, MD, Giuseppe Signoriello, MD, Paolo Calabrò, MD, PhD, Pier Francesco Rambaldi, MD, Ciro Mauro, MD, Maria Rosaria Rizzo, MD, PhD and Michelangela Barbieri, MD, PhD

ABSTRACT

Objective: Management of type 2 diabetic patients (DMT2) with non-obstructive coronary stenosis (NOCS) Non–ST-Elevation Myocardial Infarction (NSTEMI) is unclear. We evaluate the 12-month prognosis of DMT2 with NOCS-NSTEMI and compared them with a cohort of DMT2 with NSTEMI and obstructive coronary stenosis (OCS) treated with percutaneous coronary intervention (PCI). Methods: DIAbetic MYocardial COronary Non-Obstructive Stenosis (DIA-MYCONOS) was an observational study prospective study of NSTEMI DMT2 patients undergoing angiographic study. 1098 DMT2 patients with first NSTEMI undergoing coronary angiography were studied. Patients were categorized in two groups, either with or without OCS (stenosis >50%). OCS patients were treated with PCI and optimal medical therapy (n=922, 84%). NOCS patients were treated with optimal medical therapy alone (n=176, 16%). Endpoints included cardiac mortality, all-cause mortality and re-hospitalization for coronary disease and heart failure. Results: OCS-NSTEMI patients were undergoing to PCI plus medical therapy, whereas NOCS-NSTEMI patients were treated with medical therapy. Groups received similar secondary prevention therapies. 1098 patients were followed-up for 1 year. In-hospital mortality was similar (1.11 vs. 1.14%), and 1-year total mortality was 6.72% in NSTEMI patients with OCS treated with PCI and 11.93% in NSTEMI patients with NOCS treated with medical therapy (P<0.09). 18.3% of NSTEMI patients with OCS and 36.9% of NSTEMI patients with NOCS were re-hospitalized for cardiovascular diseases (P <0.05). Conclusions: NOCS-NSTEMI-DMT2 patients treated with medical therapy have poor prognoses as compared with OCS-NSTEMI patients treated with PCI, despite a less aggressive initial atherosclerosis. These findings evidence a possible gap in the NOCS-NSTEMI management.

Keywords: diabetes, myocardial infarction, coronary stenosis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )