EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SOLUBILITY ENHANCEMENT OF CANDESARTAN CILEXETIL BY USING DIFFERENT HYDROTROPIC AGENTS

Jaya Singh*, Dr.S.K.Umadevi, Sai vardhan, Manisha Lachoriya, G.Rajeswari, B.Kasturibai.

ABSTRACT

Conventional Candesartan Cilexetil is practically insoluble in water, have slow onset of action and poor bioavailability (15-20%), and therefore cannot be given in emergency clinical situations like hypertension or pulmonary edema. The purpose of research is to provide a fast dissolving oral dosage form of candesartan, which can provide quick onset of action by using the concept of mixed hydrotropy. Initially solubility of candesartan is determined individually in 4 hydrotropic agents namely urea, sodium acetate, sodium benzoate and sodium citrate at concentration of 10, 20, 30 and 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoate solution. Different combinations of all hydrotropic agents in different ratios were used to determine solubility, so that total concentration of hydrotropic agents was always 40%. Highest solubility was obtained in solution which contains (sodium acetate,sodium benzoate,sodium citrate )at optimum ratio of 13.33. This optimized combination was utilized in preparing solid dispersions by common solvent evaporation technique using distilled water as solvent. Solid dispersions were evaluated for flow properties like bulk density, tapped density, angle of repose, compressibility index, hausner ratio and SEM. Dissolution studies of solid dispersion were done using USP Type II apparatus. It was concluded that the concept of mixed hydrotropic solid dispersion is novel, safe and cost-effective technique for enhancing the bioavailability of poorly water-soluble drugs by dissolving drug in non ionized form. The magical enhancement in solubility of Candesartan Cilexetil is clear indication of its potential to be used in future for other poorly water-soluble drugs in which low bioavailability is major concern.

Keywords: Bioavailability, Candesartan Cilexetil, Mixed Hydrotropy, Solid Dispersion.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )