EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE NEUROPROTECTIVE EFFECT OF BEE VENOM AGAINST DIABETIC NEUROPATHY IN A RAT MODEL: ULTRASTRUCTURE AND MORPHOMETRIC STUDY

Walaa Baher* and Asmaa A Abo-Zeid

ABSTRACT

Context: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia that accompanied by complications such as polyneuropathy. Bee venom (BV) therapy is an old traditional remedy that has been used to treat various diseases safely. Objectives: To evaluate the effect of BV on neuropathy of sciatic nerve in streptozotocin (STZ)-induced diabetes in rats using ultrastructure and morphometric methods. Materials and Methods: Thirty adult male Wister rats were divided randomly into (group I) the negative control group, (group II) the BV control group; rats received intraperitoneal injection (IP) of 0.5 mg/kg BV twice weekly for four consecutive weeks; (group III) the STZ-induced diabetic group and (group IV) was the BV treated group. Blood glucose levels were assessed for all groups twice weekly. At the end of fourth week, animals in all groups were sacrificed and the sciatic nerves of all groups were harvested and processed for semithin sections and ultrastructure study. Total fiber diameter, axon diameter, myelin thickness and the g ratio were measured and were statistically analyzed. Results: Blood glucose level was decreased to normal in BV treated group. Statistical analysis showed that treatment with BV significantly increased (P<0.05) sciatic nerve diameter in normal and diabetic rats and the g ratio was significantly decreased in diabetic rats. The ultrastructural examination revealed that BV reversed the axonal and myelin damage and degenerative changes of axonal mitochondria and Schwann cells that occurred in diabetic rats. Conclusion: BV therapy could protect against peripheral neuropathy resulting from STZ-induced hyperglycemia.

Keywords: Diabetic neuropathy, Bee venom, axon diameter, g ratio.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )