EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF OMEGA-3 ON CARDIAC MUSCLE STRUCTURE IN A MODEL OF RHEUMATOID ARTHRITIS IN RAT. A LIGHT AND ELECTRON MICROSCOPIC STUDY

Nevine Bahaa* and Azza Abd El Moneim Attia

ABSTRACT

Background: Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis. High percent of premature mortality in RA patients was largely attributable to cardiovascular diseases. Unfortunately, no curative treatment was found for this disease yet. Omega-3 polyunsaturated fatty acids (PUFAs) were largely studied for their anti-inflammatory effects. Aim of the work: to evaluate the effect of omega-3 PUFAs on the myocardial structure of left ventricle (LV) in a model of Adjuvant-induced RA in rats. Material and methods: Thirty rats were divided into three groups; control group, RA group and omega 3-treated group. RA was induced by single subcutaneous injection of complete Freund adjuvant in hind paw of rats. Omega-3 was orally administered after two weeks of RA induction, and continued daily for another two weeks. The ankle joint and the heart were dissected out after two and four weeks and processed for light microscopic examination. Specimens from the left ventricle were also processed for transmission electron microscopic examination. Histomorphometric studies and statistical analysis were also done. Results: RA was confirmed histologically in the ankle joint after two weeks. The LV also showed focal degeneration of the myocardium, and mononuclear cellular infiltration that was more evident after four weeks of untreated RA. Omega-3 treated group showed significant decrease of myocardial structure damage. Conclusion and recommendations: Omega-3 significantly ameliorated the structural damage of LV myocardium after RA induction. It is highly recommended to use omega 3 PUFAs regularly as early as possible in RA cases.

Keywords: rheumatoid arthritis, cardiac muscle, omega 3, rats, complete Freund Adjuvant.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )