EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

THE EFFECT OF OMEGA - 3 FATTY ACIDS ON THE EXPERIMENTALLY INDUCED DIABETIC CARDIOMYOPATHY IN ADULT MALE ALBINO RATS

Eman Badawi El Shal*, Mai M.H. Selim Omaima I. Abo-Elkheir and Mona Gamal El-Din Al Anany

ABSTRACT

Introduction: Cardiovascular disease is responsible for about 80% of deaths among diabetic patients. Scientific evidence revealed that a diet rich in long chain omega -3 fatty acids help in the development of healthy brain, heart and immune system. Aim of work: The current study was designed to investigate the biochemical, histological and ultrastructural changes occurring in the diabetic heart of albino rats induced by streptozotocin (STZ) and the possible protective role of the omega-3 fatty acids. Materials and Methods: Forty five adult male albino rats were used in this study. The animals were divided into four groups, each group including 10 male rats except the group I was 15 rats. Group I (control group), Group II (Omega-3 group): was given daily oral dose of 54mg/ rat omega -3 fatty acids dissolved in corn oil. Group III (Diabetic group): this group was given single intraperitoneal injection of streptozotocin (STZ), the dose was 60mg/kg. Group IV (Diabetic and Omega-3 group): in this group the rats were given both omega-3 fatty acids and STZ. The experiment continued for 6 weeks, then blood samples were collected for blood glucose level, creatine kinase-MB (CK-MB) and troponin-I estimation and statistical study was also done. Heart specimens were processed for light and electron microscopic study. Result: Light microscopic results of Group I and II showed the usual histological architecture of the myocardium. Group III showed discontinuous, widely spaced cardiomyocytes, vascular congestion and mononuclear cellular infiltration. Ultrastructural results showed discontinuous broken myofibril, mitochondria swollen of variable shapes and sizes. The blood glucose, CK-MB and troponin-I were significantly increased. Administration of omega-3 fatty acids to the diabetic rats (group IV) ameliorates the previous changes. Conclusion: Omega-3 fatty acids administration can protect the heart in cases of diabetic cardiomyopathy.

Keywords: cardiomyopathy, STZ, omega -3 fatty acids, diabetes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )