STUDIES OF PHYSICOCHEMICAL PROPERTIES AND LIPOPHILICITY OF PYRIDAZINE DERIVATIVES: AN OVERVIEW
Massud A. S. Anwair* and Anisa Elhamili
These physicochemical properties and lipophilicities review studies cover all spectroscopy methods that were used
for the analysis of pyridazine derivatives structures such as calculation of N-N bond lengths, angles and electron
densities. These analysis indicate the planarity and N-N single bond characteristics of these derivatives and shown
no protonation or quaternization affect the bond lengths with the ring. These physicochemical properties review
studies also include tautomerism, surface tension, density, melting and boiling point of many pyridazine
derivatives. However, and due to the relationship between the biological activities and lipophilicities properties of
these compounds, so the lipophilicity and their methods of determination were also studied. Some specific
pharmacological activities such as antitumor which are related to structure activity relationship of pyridazine
derivatives have also reported.
Keywords: Pyridazine, tautomerism, quaternization.
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