EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF ANTIOXIDANT ACTIVITY AND CYTOTOXICITY OF LINUM USITATISSIMUM SEEDS

Enas Ali Hassan Alkangar*1, Elaf Badr Aldeen Osman2, Maab Yosif Osman2, Eman Adil khalifa2, Shaima Amin Mohamed Ahmed2

ABSTRACT

Linum usitatissimum (Flax) is a member of the genus Linum in the family Linaceae. The main objectives of this study is to evaluate the antioxidant activity and cytotoxicity of Linum usitatissimum seeds and to identify the solvent of the highest capacity to extract it’s antioxidant and cytotoxic components among solvent used. In this study Linum usitatissimum seeds was extracted by maceration with petroleum ether, chloroform and ethanol 70%, those yielded 8.8, 2.3 and 11.1% respectively, all extracts were analyzed by thin layer chromatograhy. The antioxidant activity and Cytotoxicity of all extracts were evaluated using DPPH method and brine shrimp lethality bioassay respectively. Phytochemical screening and thin chromatographic analysis of Linum usitatissimum were exhibited the presence of reducing sugars, essential oils, anthraquinones, terpenoids, coumarins, alkaloids, flavonoids but saponins and cardiac glycosides exhibited with TLC only. Aquatic ethanol extract accompanied with high tannin content (1.35 mg tannic acid equivalent/mg of dry extract). Evaluation of antioxidant activity and cytotoxicity revealed that no extract was induced antioxidant activity while chloroform extract was shown to have high cytotoxicity (LC50=36.4 μg/ml) among tested extracts.

Keywords: Linum usitatissimum, Antioxidant, Cytotoxicity, Thin layer chromatography.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )