EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

PRELIMINARY PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES ON THE CRUDE EXTRACT OF RED ALGAE GRACILARIA EDULIS AGAINST CLINICAL ISOLATES

Rajakumar R.* and Allwin Prem Singh Y.

ABSTRACT

Phytochemicals are naturally present in the seaweeds and are biologically significant and plays an essential role in defending themselves against various pathogenic microbes by showing the antimicrobial activity by inhibition or killing mechanisms. In the present study revealed that the preliminary phytochemical, antibacterial and antifungal activities of crude extract of Gracilaria edulis were investigated. The methanol and aqueous extracts of Gracilaria edulis showed the presence of a number of metabolites such as alkaloids, saponin, phenols, terpenoids, proteins, flavonoids, glycosides, coumarins and tannins. G.edulis showed the significant antibacterial activity against in the clinical pathogens of Pseudomonas aeroginosa, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Streptococcus pyogenes, Salmonell typhi as well as the fungus Aspergillus niger, Aspergillus flavus, Rhizopus indicus and Candida albicans. The methanol extracts of G.edulis showed maximum activity of 18mm (100μg/ml) of inhibition zone against Staphylococcus aureus and followed by the methanolic extracts of P.aerogenosa (16mm) and aqueous extract of S.aureus (14mm) when it was compared to the positive control Gentamycin. The methanol extract showed the broader spectrum of antibacterial and antifungal activity when compared with aqueous extract.

Keywords: Antimicrobial, phytochemical, Gracilaria edulis, aqueous extract.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia