EVALUATION OF SYNERGISTIC ANTIULCER POTENTIAL OF ETHANOLIC EXTRACT OF BETA VULGARIS (TAPROOT) & FICUS RELIGIOSA (BARK) IN WISTAR RATS

*Rahul Arora and Neelanchal Trivedi

ABSTRACT

Objective: To authenticate the synergistic anti-ulcer potential of the ethanolic extract of Ficus religiosa bark and Beta vulgaris root aligned with in vivo pylorus ligation assay. Methods: The root and bark of the plants were extracted by ethanol. The ethanolic extract was subjected to evaluate its phytochemical profiles. Gastric ulcers induced in male wistar rats via ligating the pylorus part of stomach. The antiulcer activity was checked by formative and comparing the ulcer index in the experimental drug groups with that of the vehicle control and standards. Omeprazole was taken as standard drug. Dose was kept as 20 mg/kg as standard and 250 & 500 mg/kg for the plant extracts. The parameters taken to evaluate antiulcer activity were gastric juice volume, free acidity, total acidity and ulcer index. Result: The obtained results were: Percent Protection (71.02% & 68.45%), Mean Ulcer Index (0.31+0.13, 0.674 + 0.279 and 0.982 + 0.415), Gastric volume (2.13 + 0.139, 2.86 + 0.101 and 3.55 + 0.194), Gastric pH (4.25 + 0.140, 3.80 + 0.201 and 3.67 + 0.098), Free Acidity (29.99 + 2.904, 69.01 + 2.03 and 63.21 + 2.994), Total Acidity (1.72 + 1.69, 35.98 + 0.44 and 72.87 + 0.244) for 20 mg/kg standard drug and 250 & 500 mg/kg of ethanolic extract of EEBV+EEFR. Conclusion: The Ethanolic extract represented a noteworthy decrease in gastric pH, free acidity and total acidity as while compared with ulcer control using Pylorus Ligation Model.

Keywords: Beta vulgaris, Ficus religiosa, Ethanolic Extract, Omeprazole, Pylorus Ligation.