EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STUDY OF IPOMOEA BATATAS EXTRACTS FOR ANTIDIABETIC ACTIVITY

Sd. Haseeb Jafferi* and Dr. M. Sunitha

ABSTRACT

The hypoglycemic effects of graded quantities (100mg/kg, 200 mg/kg and 300mg/kg/day) of Ipomea batatas leaf extracts at a dose of once daily for fourteen days on the blood glucose level of 20 rats whose glucose level exceeded 200mg/dl after alloxan induction were studied. Qualitative and quantitative analysis of phytochemical ingredients of Ipomea batatas leaf were also carried out. The results showed that oral treatment with 2ml of 200 mg/kg/day of Ipomoea batatas aqueous extract did not produce significant alterations in the blood glucose concentration level when compared with basal value. The highest percentage blood sugar reductions of 69.35% was recorded in rats treated with 200 mg/kg/day, followed by 60.16% (300mg/kg/day extract) while the least percentage sugar reduction of 52.10% was observed in 100mg/kg/day extract. The non-diabetic induced rats exhibited steady increase (8.51%) in their normal glucose level. It was revealed that alloxan induced rats treated with 100mg/kg/day, 200mg/kg/day and 300mg/kg/day sustained percentage weight loss of 49.15%, 27.95% and 31.37% respectively compared with non-diabetic induced rats. The qualitative phytochemical screening investigation of Ipomeabatata indicated the presence of alkaloids, flavonoids, tannins, saponins, steroids, phenol, anthraquinone, Phlobatannin, Glycosides and terpenoids. Also, quantitative phytochemical study revealed that saponin (6.18) was the highest phytochemical content followed by tannin (4.05) while Glycoside was the least (0.29). In conclusion, 200mg/kg/day of the extract produced the best hypoglycemic effect (69.35%) in diabetic induced rats.

Keywords: Alloxan-induced rats, Anti-diabetes, Diabetes, Ipomoea batatas, phytochemical analysis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )