STUDY OF IPOMOEA BATATAS EXTRACTS FOR ANTIDIABETIC ACTIVITY
Sd. Haseeb Jafferi* and Dr. M. Sunitha
The hypoglycemic effects of graded quantities (100mg/kg, 200 mg/kg and 300mg/kg/day) of Ipomea batatas leaf extracts at a dose of once daily for fourteen days on the blood glucose level of 20 rats whose glucose level exceeded 200mg/dl after alloxan induction were studied. Qualitative and quantitative analysis of phytochemical ingredients of Ipomea batatas leaf were also carried out. The results showed that oral treatment with 2ml of 200 mg/kg/day of Ipomoea batatas aqueous extract did not produce significant alterations in the blood glucose concentration level when compared with basal value. The highest percentage blood sugar reductions of 69.35% was recorded in rats treated with 200 mg/kg/day, followed by 60.16% (300mg/kg/day extract) while the least percentage sugar reduction of 52.10% was observed in 100mg/kg/day extract. The non-diabetic induced rats exhibited steady increase (8.51%) in their normal glucose level. It was revealed that alloxan induced rats treated with 100mg/kg/day, 200mg/kg/day and 300mg/kg/day sustained percentage weight loss of 49.15%, 27.95% and 31.37% respectively compared with non-diabetic induced rats. The qualitative phytochemical screening investigation of Ipomeabatata indicated the presence of alkaloids, flavonoids, tannins, saponins, steroids, phenol, anthraquinone, Phlobatannin, Glycosides and terpenoids. Also, quantitative phytochemical study revealed that saponin (6.18) was the highest phytochemical content followed by tannin (4.05) while Glycoside was the least (0.29). In conclusion, 200mg/kg/day of the extract produced the best hypoglycemic effect (69.35%) in diabetic induced rats.
Keywords: Alloxan-induced rats, Anti-diabetes, Diabetes, Ipomoea batatas, phytochemical analysis.
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