RESEARCH ARTICLE ON: FORMULATION & EVALUATION OF SUSTAINED RELEASE MICROSPHERE OF CEFIXIME TRIHYDRATE BY IONIC GELATION TECHNIQUE

Saurabh, Nisha Devi, Shweta Aggrwal* and Dr. R. B. Sharma

ABSTRACT

Microspheres are small spherical particles, with diameters range 1 μm to 1000 μm. They are spherical free flowing particles with size less than 200 μm and consisting of proteins or synthetic polymers which are biodegradable in nature microsphere is basically a mixture of drug, dispersed in a polymer form with release occurs by 1st order process. Microspheres are two types; microcapsules and micromatrices in case Microcapsules are those in which entrapped substance is distinctly surrounded by distinct capsule wall. And micromatrices in which entrapped substance is dispersed throughout the matrix. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. Most of sustained release dosage form follows the mechanism of diffusion, dissolution or combination of both, to produce slow release of drug at predetermined rate. Hypothetically, a sustained release dosage form should release the drug by a zero-order mechanism which maintains drug plasma level time similar to intravenous infusion. . Cefixime has high affinity for penicillin-binding proteins (PBP) 3, la and Ib. Its affinity for PBPIb explains the rapid lytic action of cefixime relative to that of the other orally active cephalosporins. The spectrum was scanned over a wave number range of 4000 cm-1 to 1 cm-1. thermogram figure 2.3 of cefixime trihydrate shows broad endothermic pea at 21 , which is its melting point as cefixime melt with decomposition over the range 21 - 225 . λmax value of cefixime trihydrate was found to be 288 nm. Finally result correlation coefficient (R2) was used as an indication of the best fit, for each of the model considered. Considering the correlation coefficient (R2) values as obtained from the different kinetic equations, the drug release from the optimized formulation F8 mainly follows zero order as best linearity was found in zero order (R2 = 0.9944) as indicated by their highest correlation coefficient value as compared with other models.

Keywords: Microsphere, Sustained release, Ionic gelation technique, Cefixime Trihydrate Drug.