EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR SIMULTANEOUS ESTIMATION OF ETORICOXIB AND PARACETAMOL IN BULK AND TABLET DOSAGE FORM BY UV- SPECTROSCOPIC METHOD

Yogesh Waghmare*, Vilas Kamble and Sonali Mahaparale

ABSTRACT

The two methods for simultaneous estimation of Etoricoxib and Paracetamol in combination of two drug tablet dosage form have been developed using Sodium Hydroxide (NaOH) as a solvent. The UV-visible Spectrophotometric method was a determination using the simultaneous or operating of the same time equation method was a determination using the simultaneous equation method at 234 nm and 254 nm. The second UV Spectrometric method is the Q-analysis (absorption ratio) method, which involves the formation of absorbance equation at 243 nm (isoabsorptive point) and at 254 nm the maximum absorption of Paracetamol. The accuracy of the methods was assessed by recovery studies was found to be 100.3 ± 0.53 and 100.4 ± 0.80 for simultaneous equation method and 96.8 ± 0.55 and 98.18 ± 0.58 for Q analysis (absorption ratio) method for Etoricoxib and Paracetamol respectively. These methods are no complicated involved also corrected and rapid those require no in preparation of the more important separation and can therefore be used for routine analysis of both drugs. The linearity ranges for Etoricoxib and Paracetamol were 4-12μg/ ml and 2-18μg/ml respectively. The linearity ranges for Etoricoxib and Paracetamol were 2-18 μg/ml and 2-10 μg/ml respectively.

Keywords: Etoricoxib, Paracetamol, UV Spectrophotometry, Q-Analysis Spectroscopic method.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )