ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR SIMULTANEOUS ESTIMATION OF ETORICOXIB AND PARACETAMOL IN BULK AND TABLET DOSAGE FORM BY UV- SPECTROSCOPIC METHOD

Yogesh Waghmare*, Vilas Kamble and Sonali Mahaparale

ABSTRACT

The two methods for simultaneous estimation of Etoricoxib and Paracetamol in combination of two drug tablet dosage form have been developed using Sodium Hydroxide (NaOH) as a solvent. The UV-visible Spectrophotometric method was a determination using the simultaneous or operating of the same time equation method was a determination using the simultaneous equation method at 234 nm and 254 nm. The second UV Spectrometric method is the Q-analysis (absorption ratio) method, which involves the formation of absorbance equation at 243 nm (isoabsorptive point) and at 254 nm the maximum absorption of Paracetamol. The accuracy of the methods was assessed by recovery studies was found to be 100.3 ± 0.53 and 100.4 ± 0.80 for simultaneous equation method and 96.8 ± 0.55 and 98.18 ± 0.58 for Q analysis (absorption ratio) method for Etoricoxib and Paracetamol respectively. These methods are no complicated involved also corrected and rapid those require no in preparation of the more important separation and can therefore be used for routine analysis of both drugs. The linearity ranges for Etoricoxib and Paracetamol were 4-12μg/ ml and 2-18μg/ml respectively. The linearity ranges for Etoricoxib and Paracetamol were 2-18 μg/ml and 2-10 μg/ml respectively.

Keywords: Etoricoxib, Paracetamol, UV Spectrophotometry, Q-Analysis Spectroscopic method.