INTRANASAL DRUG DELIVERY SYSTEM “AN OVERVIEW”
Bijal Prajapati*, Rakesh Patel and Dr. Abhay Dharamsi
Smelling tobacco and hellucinogens have been used by inhalations for centuries by different culture worldwide. Intranasal administration offers a variety of attractive options for local and systemic delivery of diverse therapeutic agents. The nasal cavity is easily accessible, rich vascular plexus permits topically administered drugs to rapidly achieve effective blood levels while avoiding intravenous catheters. Due to the high vascularity and permeability of nasal mucosa, nasal delivery is considered for both topical and systemic action and an alternative route for the administration of drugs and biomolecules that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism.
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