EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARATIVE STUDY BETWEEN PROPHYLACTIC CEFOTAXIM PLUS METRONIDAZOLE VERSUS CEFEPIME PLUS METRONIDAZOLE IN PREVENTION OF WOUND SEPSIS IN ELECTIVE GASTROINTESTINAL SURGERY

Dr. Ahmed Abd El Aal Sultan*, Dr. Mohamed Ahmed Yousef Ali and Prof. Dr. Ramadan Hassan El-Far.

ABSTRACT

Background: We compare between prophylactic cefotaxim plus metroniadazole versus cefepime plus metroniadazole before elective gastrointestinal surgery, in prevention of post-operative surgical wound infection. Objectives: To compare the efficacy of a new and possibly less expensive antibiotic prophylaxis cefepime against cefotaxim and to assess the optimal duration of antibiotic dosing required in the prevention of wound infections following elective gastrointestinal surgery. Specifically to determine: 1. If the prophylactic antibiotic decreases the risk of post operative wound infection. 2. Broad spectrum antibiotic to cover (aerobic or anaerobic bacteria, or both) (Gram positive, or Gram negative, or both). 3. The time of beginning and duration of antibiotic in take. 4. Whether any antibiotic is clearly more effective than the currently recommended gold standard specified in published guidelines. 6. If the antibiotic is taken before or after the operation. 7. If the antibiotic is taken in single dose or multiple doses. Search methods: The study will be carried out in Karmos Health Insurance Hospital in Alexandria and, Al-Azhar University Hospitals in Cairo, on fourty patients through randomized controlled prospective study, for series of patients with elective gastrointestinal surgery managed in the period between November 2016 to May 2017. Patient were followed up for two weeks after surgery and every one week for a month.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia