COMPARATIVE STUDY BETWEEN PROPHYLACTIC CEFOTAXIM PLUS METRONIDAZOLE VERSUS CEFEPIME PLUS METRONIDAZOLE IN PREVENTION OF WOUND SEPSIS IN ELECTIVE GASTROINTESTINAL SURGERY

Dr. Ahmed Abd El Aal Sultan*, Dr. Mohamed Ahmed Yousef Ali and Prof. Dr. Ramadan Hassan El-Far.

ABSTRACT

Background: We compare between prophylactic cefotaxim plus metroniadazole versus cefepime plus metroniadazole before elective gastrointestinal surgery, in prevention of post-operative surgical wound infection. Objectives: To compare the efficacy of a new and possibly less expensive antibiotic prophylaxis cefepime against cefotaxim and to assess the optimal duration of antibiotic dosing required in the prevention of wound infections following elective gastrointestinal surgery. Specifically to determine: 1. If the prophylactic antibiotic decreases the risk of post operative wound infection. 2. Broad spectrum antibiotic to cover (aerobic or anaerobic bacteria, or both) (Gram positive, or Gram negative, or both). 3. The time of beginning and duration of antibiotic in take. 4. Whether any antibiotic is clearly more effective than the currently recommended gold standard specified in published guidelines. 6. If the antibiotic is taken before or after the operation. 7. If the antibiotic is taken in single dose or multiple doses. Search methods: The study will be carried out in Karmos Health Insurance Hospital in Alexandria and, Al-Azhar University Hospitals in Cairo, on fourty patients through randomized controlled prospective study, for series of patients with elective gastrointestinal surgery managed in the period between November 2016 to May 2017. Patient were followed up for two weeks after surgery and every one week for a month.

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