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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Islam El-Garawani, Sobhy Hassab El Nabi and Eman El-Ghandour*


Etoposide is an anticancer drug that belonging to topoisomerase II inhibitors. Fennel (Foeniculum vulgare) is a medicinal plant belonging to the family Apiaceae. The present study evaluated the possible protective potential of oral simultaneous treatment of fennel oil (0.5 &1 mg/kg body weight) every 48 hours for 21 days against the genotoxic effects of etoposide intraperitoneal administration (5 mg/kg body weight) every 72 hours for 21 days on bone marrow and testis in male albino rat (Rattus norvegicus). Seventy two adult male albino rats were used as the following, 36 rats (6 for each group) were prepared for DNA, sperm head abnormalities and total protein (they were received the treatments for 21 days). The other 36 rats were used for chromosomal aberrations in bone marrow in addition to mitotic index in bone marrow and testis evaluation (they were received the treatments for 72 hours only). Animals treated with etoposide showed DNA fragmentations on agarose gel electrophoresis and a significant increase (P≤0.001) in the percentage of bone marrow total chromosomal aberrations (TCA: 230.3±1.9) with marked decrease (P≤0.01) in mitotic index in both bone marrow and testis (39.6±10.9 & 17.8±4.3) respectively. Sperm head abnormalities were significantly (P≤0.001) increased also after etoposide treatment (68.9±2.17). Total Protein contents in testis were increased after etoposide treatment. While simultaneous treatment of fennel oil (either 0.5 or 1 mg/kg b. wt.) improved the protein levels. In conclusion, the results of the present study indicated that fennel oil exerted a protective effect against genotoxicity and cytotoxicity induced by etoposide that may be due to its antioxidant effects. Consequently, we recommended that fennel oil can be suggested to be administrated as co-medicine in chemotherapeutic treatments of cancer.

Keywords: Etoposide, Fennel oil, DNA, Chromosomal aberrations, Mitotic index.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia