EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

LIGATIONAL AND SPECTROSCOPIC ON SOME SULFAMETHOXAZOLE METAL COMPLEXES AS ANTIMICROBIAL AGENTS

Yasmin M.S. Jamil, Maher Ali Al-Maqtari* and Mohammed K. Al-Qadasi

ABSTRACT

Metal complexes have been applied as medicinal agents in the treatment of differenthuman infections and diseases. So, the aim of this study is focused on studying theligational, spectroscopic and evaluating antimicrobial investigations of sulfamethoxazole (SMX)drug complexes formulas with Mn (II), Cu (II), Ni (II), Zn (II), Y(III), La(III), Nd(III) and Gd(III) metal ions. These complexes with sulfamethoxazole ligand as to evaluate thebiological activity were synthesized and characterized by elemental analysis,molar conductance, magnetic susceptibility, UV-vis, IR and1H-NMR spectroscopy. The IR spectral data suggested that the coordination sites of SMX are the sulfonyloxygen and SO2-NH sulfonamide nitrogen as a bidentateligand ,from the microanalytical data, the stoichiometry of thecomplexes 1:2 (metal: ligand) was found, and the morphological nano structures of SMX complexes were checked using X-raypowder diffraction (XRD) and scanning electron microscope (SEM). The metal complexes werescreened for antibacterial activity against Gram-ve(Escherichia coli)(ATCC 8739) andGram+ve(Staphylococcus aureus)(ATCC 8739) and antifungal (Aspergillusflavus(ATCC 9643)and Aspergillusfumigatus(ATCC 1022)). These complexes considered in this research showed as a satisfactory antimicrobial activity.

Keywords: Sulfamethoxazole, lanthanides, nano size, antimicrobial activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia